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cd2665  (Tocris)
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Tocris cd2665
RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), <t>RARβ</t> agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.
Cd2665, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cd2665/product/Tocris
Average 93 stars, based on 1 article reviews
cd2665 - by Bioz Stars, 2026-04
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rarγ antagonists cd2665  (Tocris)
94
Tocris rarγ antagonists cd2665
RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), <t>RARβ</t> agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.
Rarγ Antagonists Cd2665, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rarγ antagonists cd2665/product/Tocris
Average 94 stars, based on 1 article reviews
rarγ antagonists cd2665 - by Bioz Stars, 2026-04
94/100 stars
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retinoic acid receptors rar antagonists cd2665  (Tocris)
94
Tocris retinoic acid receptors rar antagonists cd2665
RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), <t>RARβ</t> agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.
Retinoic Acid Receptors Rar Antagonists Cd2665, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/retinoic acid receptors rar antagonists cd2665/product/Tocris
Average 94 stars, based on 1 article reviews
retinoic acid receptors rar antagonists cd2665 - by Bioz Stars, 2026-04
94/100 stars
  Buy from Supplier
retinoic acid receptor antagonist cd2665  (Tocris)
94
Tocris retinoic acid receptor antagonist cd2665
RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), <t>RARβ</t> agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.
Retinoic Acid Receptor Antagonist Cd2665, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/retinoic acid receptor antagonist cd2665/product/Tocris
Average 94 stars, based on 1 article reviews
retinoic acid receptor antagonist cd2665 - by Bioz Stars, 2026-04
94/100 stars
  Buy from Supplier

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RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), RARβ agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.

Journal: bioRxiv

Article Title: Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice

doi: 10.1101/2024.11.08.622655

Figure Lengend Snippet: RARγ agonists strongly affect cultured chondrocyte function. Epiphyseal chondrocytes isolated from neonatal mice were treated with vehicle ethanol, retinoic acid (100 nM, RA), RARα agonist (AGN195183, 300 nM), RARβ agonist (BMS453, 300 nM) or RARγ agonist (NRX204647, 100 nM) 2 days after plating. A, Phase contrast images 4 days after treatment. B, Total RNAs were prepared 4 days after treatment and subjected to qPCR to examine expression levels of Sox 9 , Acan , Col9a1 , Ihh , C ol10a1 , Mmp3 and Tnfs11 ( Rankl ). n=3/group. Individual values, average and standard deviation (SD) are shown.

Article Snippet: Retinoic acid, BMS453 (RARβ agonist, CAS166977-43-1) and CD2665 (RARβ/γ antagonist, CAS 170355-78-9) were purchased from Tocris Biosciences (Bristol, UK).

Techniques: Cell Culture, Isolation, Expressing, Standard Deviation

RARγ signaling dominantly affects skeletal growth. A-C, C57BL/6J female mice were treated with corn oil (Control), selective agonists of RARα (AGN195183, 4 mg/kg), RARβ (BMS453, 4 mg/Kg), RARγ (NRX204647, 1 mg/Kg) or antagonist for RARγ (CD2665 and 7C, 4 mg/kg) via peritoneal injections (11 days of age) or gavage (over 14 days of age) starting at 11 days of age every other day. The hind limbs were harvested at and subjected to radiological examination. (A) Gross appearance 8 days after initial treatment (19 days of age). (B) Radiological views of the knee joints 8 days after initial treatment (19 days of age). Arrows indicate the proximal tibial growth plate. Note RARγ-agonist treated group (right panel) showed closure of growth plate. (C) Body length was measured 8 days after initial treatment (19 days of age). D, C57BL/6J female and male mice were treated with corn oil (Control) or selective agonists of RARγ (NRX204647, 1 mg/Kg) via peritoneal injections starting at 14 days of age every other day. The hind limbs were harvested at 22 days of age and subjected to radiological examination. The tibia and femur lengths were measured by ImageJ. Individual values, average and standard deviation (SD) are shown.

Journal: bioRxiv

Article Title: Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice

doi: 10.1101/2024.11.08.622655

Figure Lengend Snippet: RARγ signaling dominantly affects skeletal growth. A-C, C57BL/6J female mice were treated with corn oil (Control), selective agonists of RARα (AGN195183, 4 mg/kg), RARβ (BMS453, 4 mg/Kg), RARγ (NRX204647, 1 mg/Kg) or antagonist for RARγ (CD2665 and 7C, 4 mg/kg) via peritoneal injections (11 days of age) or gavage (over 14 days of age) starting at 11 days of age every other day. The hind limbs were harvested at and subjected to radiological examination. (A) Gross appearance 8 days after initial treatment (19 days of age). (B) Radiological views of the knee joints 8 days after initial treatment (19 days of age). Arrows indicate the proximal tibial growth plate. Note RARγ-agonist treated group (right panel) showed closure of growth plate. (C) Body length was measured 8 days after initial treatment (19 days of age). D, C57BL/6J female and male mice were treated with corn oil (Control) or selective agonists of RARγ (NRX204647, 1 mg/Kg) via peritoneal injections starting at 14 days of age every other day. The hind limbs were harvested at 22 days of age and subjected to radiological examination. The tibia and femur lengths were measured by ImageJ. Individual values, average and standard deviation (SD) are shown.

Article Snippet: Retinoic acid, BMS453 (RARβ agonist, CAS166977-43-1) and CD2665 (RARβ/γ antagonist, CAS 170355-78-9) were purchased from Tocris Biosciences (Bristol, UK).

Techniques: Control, Standard Deviation